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KMID : 1007520120210051469
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Food Science and Biotechnology
2012 Volume.21 No. 5 p.1469 ~ p.1475
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Potential Mechanism of Kaempferol against Cu2+-induced Oxidative Stress through Chelating Activity and Regulation of Nuclear Factorerythroid- 2-related Factor 2 Signaling
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Kim Gyo-Nam
Kim Eui-Su
Kwon Young-In
Jang Hae-Dong
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Abstract
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Metal ions play important roles in various biological processes of living systems. However, the generation of reactive oxygen species (ROS) is also closely linked with the participation of redox-active metal ions such as copper, iron, chromium, and cobalt ions. Excessive production of ROS by redox-active metal ions can cause oxidative stress and further oxidative stress-related diseases. This study shows the results of the antioxidant activity of kaempferol in both ORACOH· and Cu2+-treated HepG2 cells. Preventive mechanism of kaempferol in Cu2+-treated HepG2 cells is also elucidated. These results suggest that both cellular Cu2+-chelating activity and expression of phase II detoxifying enzymes such as HO-1 and GSTA2 through activating Nrf2 are required for cellular antioxidant activity of kaempferol in Cu2+-treated HepG2 cells. Our findings provide the scientific evidence for the development of Nrf2 targeting dietary antioxidant to prevent oxidative stressrelated conditions.
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KEYWORD
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kaempferol, Cu2+-chelating activity, cellular antioxidant activity, nuclear factor-erythroid-2-related factor 2, heme oxygenase-1
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